Item Build
Starting Items
you start with 475g
Against good matchups like Sivir, Ezreal, Kog'maw.
Core Build
Flex Items
last 2 items are optional, Last Whisper if they built armor...
Against Hard Matchups
Core Build
Flex Items
You can invent new build too and try them out which fits the situations throughout the games.
Summoner Spells
Cleanse against hard cc supports.
Depends on the meta whether enemy supports go ignite therefore Barrier or if they go for any other sum then Heal.
Skill Order
(Q)›
(W)›
(E)| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Q | Q | Q | Q | Q | |||||||||||||
| W | W | W | W | W | |||||||||||||
| E | E | E | E | E | |||||||||||||
 | R | R | R |
You can max 'W' before 'Q' ( Situational ).
Runes
9× Mark of Attack Damagemark
9× Seal of Armorseal
9× Glyph of Magic Resistglyph
3× Quintessence of Life Stealquint
Quintessence : 3x Attack Speed or Attack Damage.
For Quintessence, you can go life steal if you feel like you will be getting poked the whole game.
Marks : Vayne is weak early game so going 9x Attack damage is great.
Seals : 9x Seal of Armor .
Glyphs : 9x Glyph of Magic resist.
Masteries
4/4
4/4
3/3
1/1
2/2
2/2
1/1
3/3
1/1
1/1
4/4
3/3
1/1
In Defense, if you face an APC, put 3 points into Resistance for Magic Resist otherwise, put 3 points into Hardiness for Armor.
Champion Select
Throughout champ select, if you see the enemy team has a heavy 'tank' comp then Vayne destroys them.
Great : Good Champions to suggest for your support 'Nunu' , 'Taric' , 'Thresh' , 'Blitzcrank' , 'Leona' , 'Nautilus' or 'Zilean'
Hard : If you are willing to play Vayne against a hard matchup then ask your support to go 'Janna' , 'Alistar' , 'Lulu' , 'Soraka' , 'Nami' , 'Morgana' or 'Sona'
^ Some champs aren't in League Classic yet as of 7/30/2026.
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